Effect of zinc supplementation on cell growth and lipoprotein binding in human fibroblast cells
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Effect of zinc supplementation on cell growth and lipoprotein binding in human fibroblast cells by Tomoko Shimakawa

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Published .
Written in English


  • Fibroblasts.,
  • Zinc -- Physiological effect.

Book details:

Edition Notes

Statementby Tomoko Shimakawa.
The Physical Object
Pagination[10], 67 leaves, bound :
Number of Pages67
ID Numbers
Open LibraryOL14241144M

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  2. Zinc Homeostasis. The human body contains 2–3 g zinc, and nearly 90% is found in muscle and bone [].Other organs containing estimable concentrations of zinc include prostate, liver, the gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas [6–8].Oral uptake of zinc leads to absorption throughout the small intestine and distribution subsequently occurs via the serum Cited by: Zinc and apoptosis. The maintenance of discrete subcellular pools of zinc is critical for the functional and structural integrity of cells. Among the important biological processes influenced by Zn is apoptosis, a process that is important in cellular homeostasis It has also been identified as a major mechanism contributing to cell death in response to toxins and in disease, offering hope Cited by:   Zinc deficiency in animals is characterized by growth inhibition and decreased food intake. Although zinc was first recognized as essential for growth in rats > 65 y ago (Todd et al. ), the first limiting role of zinc in growth has not been d food intake occurs within 4–5 d of feeding a zinc-depleted diet to rats (Giugliano and Millward ), hence an energy deficit could Cited by: On the other hand, three studies observed a positive effect of zinc supplementation on triglycerides, and two found an effect on Low-Density Lipoprotein (LDL-c) and total cholesterol.

Recent global estimates indicate that over a quarter of children under 5 years of age are stunted, and consequently are at an increased risk of dying and other adverse consequences throughout life. Zinc is known to play a critical role in biological processes including cell growth, differentiation and metabolism 4,5 and deficiency in this micronutrient restricts childhood growth and. 1. Introduction. Human prostatic carcinoma is one of the most common cancers among men and the second leading cause of cancer-related te cancer cell growth is controlled by several factors, including androgen, growth factors, and their respective receptors,.Among the most commonly reported changes, increase in autocrine and paracrine growth factor loops is strongly correlated Cited by:   Zinc supplements can significantly inhibit the proliferation of esophageal cancer cells, according to a new study co-authored by a University of Texas at Arlington researcher.   The present study investigated how modulation of cellular zinc availability affects β-cell function using INS-1E cells. Using INS-1E cells, we found that zinc supplementation and zinc chelation had significant effects on insulin content and insulin secretion. Supplemental zinc within the physiological concentration range induced insulin by:

Zinc deficiency is defined either as insufficient zinc to meet the needs of the body, or as a serum zinc level below the normal range. However, since a decrease in the serum concentration is only detectable after long-term or severe depletion, serum zinc is not a reliable biomarker for zinc status. Common symptoms include increased rates of lty: Endocrinology.   Zinc supplementation has been shown to improve T cell–mediated function (1, 6, 14–18) and to reduce infections in the elderly. Zinc supplementation may therefore play an important role in increasing serum zinc concentrations, improving immunity, and preventing infectious diseases such as pneumonia in the elderly (1, 5, 7).Cited by: Zinc is an essential element in cell culture. However, classical media do not typically contain it in their basal formulations. This is because sera used at 5 to 10% provides sufficient zinc for cell growth and survival. Efforts to develop serum-free media necessitate the addition of zinc to the cell culture system. Effect of Zinc on Cells and Biomembranes Milos Chvapil, MD., Ph.D., It is becoming increasingly evident that zinc ions as an integral part of tissues and biologic fluids are one of many homeostatic mechanisms regulating the reactivity of tissues and by: